PUBLICATIONS

Publications

2021

Detection of cell-free microbial DNA using a contaminant-controlled analysis framework

Genome Biology

E. Zozaya-Valdes, S.Q. Wong, J. Raleigh, A. Hatzimihalis, S. Ftouni, A.T. Papenfuss, S. Sandhu, M.A. Dawson, S.J. Dawson*
2021, Jun 23;22(1):187
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HIV is associated with an increased risk of age-related clonal haematopoiesis among older adults: the ARCHIVE study

Nature Medicine

N.J. Dharan, P. Yeh, M. Bloch, M.M. Yeung, D. Baker, J. Guinto, N. Roth, S. Ftouni, K. Ognenovska, D. Smith, J.F. Hoy, I. Woolley, C. Pell, D.J. Templeton, N. Fraser, N. Rose, J. Hutchinson, K. Petoumenos*, S.J. Dawson*, M.N. Polizzotto*, M.A. Dawson*
2021 Jun;27(6):1006-1011
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Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling

Nature Communications

I.A. Vergara, C.P. Mintoff, S. Sandhu, L. McIntosh, R.J. Young, S.Q. Wong, A. Colebatch, D.L. Cameron, J.L. Kwon, R. Wolfe, A.Peng, J. Ellul, X. Dou, C. Fedele, S. Boyle, G. Mir Arnau, J. Raleigh, A. Hatzimihalis, P. Szeto, J. Mooi, D.S. Widmer, P.F. Cheng, V. Amann, R. Dummer, N. Hayward, J. Wilmott, R.A. Scolyer, R.J. Cho, D.D. Bowtell, H. Thorne, K. Alsop, S. Cordner, N. Woodford, J. Leditschke, P. O'Brien, S.J.Dawson, G.A. McArthur, G.J. Mann, M.P. Levesque, A.T. Papenfuss, M. Shackleton
2021 Mar 4;12(1):1434
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Towards routine implementation of liquid biopsies in cancer management: It is always too early, until suddenly it is too late

Diagnostics

M.J. IJzerman, J. de Boer, A. Azad, K. Degeling, J. Geoghegan, C. Hewitt, F. Hollande, B. Lee, Y.H. To, R.W. Tothill, G. Wright, J. Tie, S.J. Dawson*
2021, Jan 11; 11(1):103
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BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation

Science Advances

Z. Vershinin, M. Feldman, T. Werner, L.E. Weil, M. Kublanovsky, E. Abaev-Schneiderman, M. Sklarz , E.Y.N. Lam , K. Alasad, S. Picaud, B. Rotblat, R.A. McAdam, V. Chalifa-Caspi, M. Bantscheff, T. Chapman, H.D. Lewis, P. Filippakopoulos, M.A. Dawson, P. Grandi, R.K. Prinjha, D. Levy
2021 May 26;7(22): eabf5374
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CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity

Nature Cancer

A.C. Watt, P. Cejas, M.J. DeCristo, O. Metzger-Filho, E.Y.N. Lam, X. Qiu, H. BrinJones, N. Kesten, R. Coulson, A. Font-Tello, K. Lim, R. Vadhi, V.W. Daniels, J. Montero, L. Taing, C.A. Meyer, O. Gilan, C.C. Bell, K.D. Korthauer, C. Giambartolomei, B. Pasaniuc, J.H. Seo, M.L. Freedman, C. Ma, M.J. Ellis, I. Krop , E. Winer, A. Letai, M. Brown , M.A. Dawson, H.W. Long, J.J. Zhao, S. Goel
2021 Jan;2(1):34-48
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2020

Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models

Blood Advances

E. Morrish, A. Copeland, D.M. Moujalled, J.A. Powell, N. Silke, A. Lin, K.E. Jarman, J.J. Sandow, G. Ebert, L. Mackiewicz, J.A. Beach, E.L. Christie, A.C. Lewis, G. Pomilio, K.C. Fischer, L. MacPherson, D.D. Bowtell, A.I. Webb, M. Pellegrini, M.A. Dawson, S.M. Pitson, A.H. Wei, J. Silke, G. Brumatti
2020 Oct 27; 4(20): 5062–5077
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Circulating tumor DNA in metastatic breast cancer to guide clinical trial enrolment and precision oncology: a cohort study

PLoS Medicine

A. Zivanovic Bujak, C.F. Weng, M.J. Silva, M. Yeung, L. Lo, S. Ftouni, C. Litchfield, Y.A. Ko, K. Kuykhoven, C. van Geelen, S. Chandrashekar, M.A. Dawson, S. Loi, S.Q. Wong, S.J. Dawson *
2020, Oct 1; 17(10):e1003363
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Clinical implications of prospective genomic profiling of metastatic breast cancer patients

Breast Cancer Research

C. van Geelen, P. Savas, Z.L. Teo, S. Luen, C-F. Weng, Y-A. Ko, K. S. Kuykhoven, F. Caramia, R. Salgado, P. A. Francis, S.J. Dawson, S.B. Fox, A. Fellowes, S. Loi
2020 Aug 18; 22(1): 91
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Circulating tumour DNA predicts outcome from first-, but not second-line treatment and identifies melanoma patients who may benefit from combination immunotherapy

Clinical Cancer Research

G. Marsavela, J. Lee, L. Calapre, S.Q. Wong, M.R. Pereira, A.C. McEvoy, A.L. Ried, C. Robinson, L. Warburton, A. Abed, M.A. Khattak, T.M. Meniawy, S.J. Dawson, S. Sandhu, M.S. Carlino, A.M. Menzies, R.A. Scolyer, G.V. Long, B. Amnuel, M. Millward, M.R. Ziman, H. Rizos, E.S. Gray
2020 Nov 15; 26 (22):5926-5933
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Longitudinal monitoring of ctDNA in patients with melanoma and brain metastases treated with immune checkpoint inhibitors

Clinical Cancer Research

J.H. Lee, A.M. Menzies, M.S. Carlino, A.C. McEvoy, S. Sandhu, A.M. Weppler, R.J. Diefenbach, S.J. Dawson, R.F. Kefford, M.J. Millward, Z. Al-Ogaili, T. Tra, E.S. Gray, S.Q. Wong, R.A. Scolyer, G.V. Long, H. Rizos
2020 Aug 1; 26 (15): 4064-4071
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Selective targeting of BD1 and BD2 of the BET proteins in cancer and immune-inflammation

Science

O. Gilan, I. Rioja, K. Knezevic, M.J. Bell, M.M. Yeung, N.R. Harker, E.Y.N. Lam, C.W. Chung, P. Bamborough, M. Petretich, M. Urh, S.J. Atkinson, A.K. Bassil, E.J. Roberts, D. Vassiliadis, M.L. Burr, A.G.S. Preston, C. Wellaway, T. Werner, J.R. Gray, A.M. Michon, T. Gobbetti, V. Kumar, P.E. Soden, A. Haynes, J. Vappiani, D.F. Tough, S. Taylor, S.J. Dawson, M. Bantscheff, M. Lindon, G. Drewes, E.H. Demont, D.L. Daniels, P. Grandi, R.K. Prinjha*, M.A. Dawson*
2020 Apr 24; 368(6489):387-394
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Coding and non-coding drivers of mantle-cell lymphoma identified through exome and genome sequencing

Blood

P. Pararajalingam, K.M. Coyle, S. Arthur, N. Thomas, M. Alcaide, B. Meissner, M. Boyle, Q. Qureshi, B.M. Grande, C. Rushton, G.W. Slack, A. Mungall, C. Tam, R. Agarwal, S.J. Dawson, G. Lenz, S. Balasubramanian, R.D. Gascoyne, C. Steidl, J. Connors, D. Villa, T.E Audas, M.A Marra, N.A. Johnson, D.W. Scott, R.D. Morin
2020 Jul 30;136(5):572-584
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RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET inhibition in RET-driven malignancies

Journal of Thoracic Oncology

B.J. Solomon, L. Tan, J.J. Lin, S.Q. Wong, S. Hollizeck, K. Ebata, B.B. Tuch, S. Yoda, J.F. Gainor, L.V. Sequist, G.R. Oxnard, O. Gautschi, A. Drilon, V. Subbiah, C. Khoo, E.Y. Zhu, M. Nguyen, D. Henry, K.R. Condroski, G.R. Kolakowski, E. Gomez, J. Ballard, A.T. Metcalf, J.F. Blake, S.J. Dawson, W. Blosser, L.F. Stancato, B.J. Brandhuber, S. Andrews. B.G. Robinson, S.M. Rothenberg
2020 April; 15(4) 541-549
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HBO1 is required for the maintenance of leukaemia stem cells

Nature

L. MacPherson, J. Anokye, M.M. Yeung, E.Y.N. Lam, Y.C. Chan, C.F. Weng, P. Yeh, K. Knezevic, M.S. Butler, A. Hoegl, K.L. Chan, M.L. Burr, L.J. Gearing, T. Willson, J. Liu, J. Choi, Y. Yang, R.A. Bilardi, H. Falk, N. Nguyen, P. Stupple, T.S. Peat, M. Zhang, M. de Silva, C. Carrasco-Pozo, V.M. Avery, P.S. Khoo, O. Dolezal, M.L. Dennis, S. Nuttall, R. Surjadi, J. Newman, B. Ren, D.J. Leaver, Y. Sun, J.B. Baell, O. Dovey, G.S. Vassiliou, F. Grebien, S.J. Dawson, I.P. Street, B.J. Monahan, C.J. Burns, C. Choudhary, M.E. Blewitt, A.K. Voss, T. Thomas, M.A. Dawson*
2020 Jan; 577(7789):266-270
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Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia

Nature Communications

Ö. Deniz, M. Ahmed, C.D. Todd, A. Rio-Machin, M.A. Dawson, M.R. Branco
2020 Jul 14;11(1):3506
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An Erg-driven transcriptional program controls B cell lymphopoiesis

Nature Communications

A.P. Ng, H.D. Coughlan, S. Hediyeh-zadeh, K. Behrens, T.M. Johanson, M. Low, C.C. Bell, O. Gilan, Y.C. Chan, A.J. Kueh,  T. Boudier, R. Feltham, A. Gabrielyan, L. DiRago,  C.D. Hyland,  H. Ierino, S. Mifsud, E. Viney, T. Willson, M.A. Dawson, R.S. Allan, M.J. Herold, K. Rogers, D.M. Tarlinton, G.K. Smyth, M.J. Davis, S.L. Nutt & W.S. Alexander
2020 Jul 14;11(1):3506
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A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells

Nature Communications

L. Guo, J. Li, H. Zeng, A.G. Guzman, T. Li, M. Lee, Y. Zhou, M.A. Goodell, C. Stephan, P.J.A. Davies, M.A. Dawson, D. Sun, Y. Huang
2020 Feb 6;11(1):740
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2019

An evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer

Cancer Cell

M.L. Burr*, C.E. Sparbier, K.L. Chan, Y.C. Chan, A. Kersbergen, E.Y.N. Lam, E. Azidis-Yates, D. Vassiliadis, C.C. Bell, O. Gilan, S. Jackson, L. Tan, S.Q. Wong, S. Hollizeck, E.M. Michalak, H. Siddle, M.T. McCabe, R.K. Prinjha, B.J. Solomon, S. Sandhu, S.J. Dawson, P.A. Beavis, R.W. Tothill, C. Cullinane, P.J. Lehner, K.D. Sutherland, M.A. Dawson*
2019 Oct 14;36(4):385-401
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Interconversion between tumorigenic and differentiated states in acute myeloid leukemia

Cell Stem Cell

M.D. McKenzie, M. Ghisi, E.P. Oxley, S. Ngo, L. Cimmino, C. Esnault, R. Liu, J. M. Salmon, C.C. Bell, N. Ahmed, M. Erlichster, M.T. Witkowski, G.J. Liu, M. Chopin, A. Dakic, E. Simankowicz, G. Pomilio, T. Vu, P. Krsmanovic, S. Su, L. Tian, T.M. Baldwin, D.A. Zalcenstein, L. DiRago, S. Wang, D. Metcalf, R.W. Johnstone, B.A. Croker, G.I. Lancaster, A.J. Murphy, S.H. Naik, S.L. Nutt, V. Pospisil, T. Schroeder, M. Wall, M.A. Dawson, A.H. Wei, H. De Thé, M.E. Ritchie, J. Zuber, R.A. Dickins
2019 Aug 1;25(2):258-272
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BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity

Epigenetics & Chromatin

P. Khoueiry, A. Ward Gahlawat, M. Petretich, A.M. Michon, D. Simola, E.Y.N. Lam, E.E. Furlong, V. Benes, M.A. Dawson, R.K. Prinjha, G. Drewes & P. Grandi
2019 Jul 2;12(1):39
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Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia

Nature Communications

C.C. Bell, K.A. Fennell, Y.C. Chan, F. Rambow, M.M. Yeung, D. Vassiliadis, L. Lara, P. Yeh, L. Martelotto, A. Rogiers, B.E. Kremer, O. Barbash, H.P. Mohammad, T.M. Johanson, M.L. Burr, A. Dhar, N. Karpinich, L. Tian, D.S. Tyler, L. MacPherson, J. Shi, N. Pinnawala, C.Y. Fong, A. Papenfuss, S. Grimmond, S.J. Dawson, R.S. Allan, R. Kruger, C.R. Vakoc, D. Goode, S. Naik, O. Gilan, E.Y.N. Lam, J.C. Marine, R.K. Prinjha, M.A. Dawson*
2019 Jun 20;10(1):2723
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Prediction and monitoring of relapse in stage III melanoma using circulating tumor DNA

Annals of Oncology

L. Tan, S. Sandhu, R.J. Lee, J. Li, J. Callahan, S. Ftouni, N. Dhomen, P. Middlehurst, A. Wallace, J. Raleigh, A. Hatzimihalis, M.A. Henderson, M. Shackleton, A. Haydon, V. Mar, D.E. Gyorki, D. Oudit, M.A. Dawson, R.J. Hicks, P. Lorigan, G.A. McArthur, R. Marais*, S.Q. Wong* & S.J. Dawson*
2019 May 1;30(5):804-814
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Dynamic molecular monitoring reveals that SWI/SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

Nature Medicine

R. Agarwal, Y.C. Chan, C.S. Tam, T. Hunter, D. Vassiliadis, C. Teh, R. Thijssen, P. Yeh, S.Q. Wong, S. Ftouni, E.Y.N. Lam, M.A. Anderson, C. Pott, O. Gilan, C.C. Bell, K. Knezevic, P. Blombery, K. Rayeroux, A. Zordan, J. Li, D.C.S. Huang, M. Wall, J.F. Seymour, D. Gray, A.W. Roberts, M.A. Dawson* & S.J. Dawson*
2019 Jan;25(1):119-129
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Circulating tumor DNA in HER2 amplified breast cancer: a translational research substudy of the NeoALTTO phase III trial

Clinical Cancer Research

F. Rothé, M.J. Silva, D. Venet, C. Campbell, I. Bradbury, G. Rouas, E. de Azambuja, M. Maetens, D. Fumagalli, V. Rodrik-Outmezguine, S. Di Cosimo, D.D. Rosa, S.K. Chia, A.M. Wardley, T. Ueno, W. Janni, J. Huober, J. Baselga, M. Piccart, S. Loi, C. Sotiriou, S.J. Dawson*, M. Ignatiadis*
2019 Jun 15; 25(12): 3581-3588
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A phase 1b dose-escalation and expansion study of the BCL-2 inhibitor venetoclax combined with tamoxifen in ER and BCL-2 positive metastatic breast cancer

Cancer Discovery

S.W. Lok, J.R. Whittle, F. Vaillant, C.E. Teh, L.L. Lo, A.N. Policheni, A.R.T. Bergin, J. Desai, S. Ftouni, L.C. Gandolfo, D. Liew, H.K. Liu, G.B. Mann, K. Moodie, A. Murugasu, B. Pal, A.W. Roberts, M.A. Rosenthal, K. Shackleton, M.J. Silva, Z.R. Siow, G.K. Smyth, L. Taylor, A. Travers, B. Yeo, M. Yeung, A. Zivanovic Bujak, S.J. Dawson, D.H.D. Gray, J.E. Visvader, G.J. Lindeman
2019 Mar; 9(3):354-369
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2018

Effects of collection and processing procedure on plasma circulating cell-free DNA from cancer patients

The Journal of Molecular Diagnostics

B. Risberg, D.W.Y. Tsui, H. Biggs, A. Ruiz-Valdepenas Martin de Almagro, S.J.Dawson, C. Hodgkin, L. Jones, C. Parkinson, A. Piskorz, F. Marass, D. Chandrananda, E. Moore, J. Morris, V. Plagnol, N. Rosenfeld, C. Caldas, J.D. Brenton, D. Gale
2018 Nov; 20(6): 883-892
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Ibrutinib plus Venetoclax for the Treatment of Mantle Cell Lymphoma

The New England Journal of Medicine

C.S. Tam, M.A. Anderson, C. Pott, R. Agarwal, S. Handunnetti, R.J. Hicks, K. Burbury, G. Turner, J. Di Iulio, M. Bressel, D. Westerman, S. Lade, M. Dreyling, S.J. Dawson, M.A. Dawson, J.F. Seymour, A.W. Roberts
2018 Mar 29; 378(13):1211-1233
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5-Formylcytosine organizes nucleosomes and forms Schiff base interactions with histones in mouse embryonic stem cells

Nature Chemistry

E.A. Raiber, G. Portella, S. Martínez Cuesta, R. Hardisty, P. Murat, Z. Li, M. Iurlaro, W. Dean, J. Spindel, D. Beraldi, Z. Liu, M.A. Dawson, W. Reik, S. Balasubramanian
2018 Dec;10(12):1258-1266
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Multiplexed proteome dynamics profiling reveals mechanisms controlling protein homeostasis

Cell

M.M. Savitski, N. Zinn, M. Faelth-Savitski, D. Poeckel, S. Gade, I. Becher, M. Muelbaier, A.J. Wagner, K. Strohmer, T. Werner, S. Melchert, M. Petretich, A. Rutkovska-Klute, J. Vappiani, H. Franken, M. Steidel, G.M. Sweetman, O. Gilan, E.Y.N. Lam, M.A. Dawson, R.K. Prinjha, P. Grandi, G. Bergamini, M. Bantscheff
2018; Mar 22;173(1):260-274
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2017

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

Nature

M. Burr*, C.E. Sparbier, Y.C. Chan, J.C. Williamson, K. Woods, P.A. Beavis, E.Y.N. Lam, M.A. Henderson, C.C. Bell, S. Stolzenburg, O. Gilan, S. Bloor, T. Noori, D. Morgens, M.C. Bassik, P.J. Neeson, A. Behren, P.K. Darcy, S.J. Dawson, I. Voskoboinik, J. Trapani, J. Cebon, P.J. Lehner*, M.A. Dawson*
2017 Sep 7; 549(7670): 101-105
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Design, synthesis and biological activity of potent 1,2,3-triazolobenzodiazepine BET bromodomain inhibitors

ACS Medicinal Chemistry Letters

P.P. Sharp, J.M. Garnier, T. Hatfaludi, Z. Xu, D. Segal, K.E. Jarman, H. Jousset, A. Garnham, J. Feutrill, A. Cuzzupe, P. Hall, S. Taylor, C.R. Walkley, D. Tyler, M.A. Dawson, P. Czabotar, A.F. Wilks, S. Glaser, D.C.S. Huang, C.J. Burns
2017 Nov 14;8(12):1298-1303
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Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation

EMBO Reports

I.G. House, C.M. House, A.J. Brennan, O. Gilan, M.A. Dawson, J.C. Whisstock, R.H.P. Law, J.A. Trapani, I. Voskoboinik
2017 Oct;18(10):1775-1785
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Click Chemistry Enables Preclinical Evaluation of Targeted Epigenetic Therapies

Science

D.S. Tyler, J. Vappiani, T. Cañeque, E.Y.N. Lam, A. Ward, O. Gilan, Y.C. Chan, A. Hienzsch, A. Rutkowska, T. Werner, A.J. Wagner, D. Lugo, R. Gregory, C. Ramirez Molina, N. Garton, C.R. Wellaway, S. Jackson, L. MacPherson, M. Figueiredo, S. Stolzenburg, C.C. Bell, C. House, S.J. Dawson, E.D. Hawkins, G. Drewes, R.K. Prinjha, R. Rodriguez, P. Grandi* & M.A. Dawson*
2017 Jun 30;356 (6345):1397-1401
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Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Blood

N. Hein, D.P. Cameron, K.M. Hannan, N.N. Nguyen, C.Y. Fong, J. Sornkom, M. Wall, M. Pavy, C. Cullinane, J. Diesch, J.R. Devlin, A.J. George, E. Sanij, J. Quin, G. Poortinga, I. Verbrugge, A. Baker, D. Drygin, S.J. Harrison, J.D. Rozario, J.A. Powell, S.M. Pitson, J. Zuber, R.W. Johnstone, M.A. Dawson, M.A. Guthridge, A. Wei, G.A. McArthur, R.B. Pearson, R.D. Hannan
2017, May 25;129(21):2882-2895
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Circulating tumor DNA analysis and functional imaging provide complementary approaches for comprehensive disease monitoring in metastatic melanoma

Journal of Clinical Oncology Precision Oncology

S.Q. Wong, J.M. Raleigh, J. Callahan, I.A. Vergara, S. Ftouni, A. Hatzimihalis, A.J. Colebatch, J. Li, T. Semple, K. Doig, C. Mintoff, D. Sinha, P. Yeh, M.J. Silva, K. Alsop, H. Thorne, D.D. Bowtell, D.E. Gyorki, G. Mir Arnau, C. Cullinane, D. Kee, B. Brady, F. Kelleher, M.A. Dawson, A.T. Papenfuss, M. Shackleton, R.J. Hicks, G.A. McArthur, S. Sandhu* & S.J. Dawson*
2017, July
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Reversion of BRCA1/2 germline mutations detected in circulating tumor DNA from high-grade serous ovarian cancer patients

Journal of Clinical Oncology

E.L. Christie, S. Fereday, K. Doig, S. Pattnaik, The Australian Ovarian Cancer Study Group, S.J. Dawson, D.D. Bowtell
2017, April 20; 35(12): 1274-1280
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Circulating tumor DNA reflects treatment response and clonal evolution in chronic lymphocytic leukemia

Nature Communications

P. Yeh, T. Hunter, D. Sinha, S. Ftouni, E. Wallach, D. Jiang, Y.C. Chan, S.Q. Wong, M.J. Silva, R. Vedururu, K. Doig, E.Y.N. Lam, G. Mir Arnau, T. Semple, M. Wall, A. Zivanovic, R. Agarwal, P. Petrone, K. Jones, D. Westerman, P. Blombery, J. Seymour, A. Papenfuss, M.A. Dawson, C.S. Tam, S.J. Dawson*
2017, Mar 17; (8):14756
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Molecular disease monitoring using circulating tumour DNA in myelodysplastic syndromes

Blood

P. Yeh, M. Dickinson, S. Ftouni, T. Hunter, D. Sinha, S. Wong, R. Agarwal, R. Veduru, K. Doig, C. Fong, P. Blombery, D. Westerman, M.A. Dawson*, S.J. Dawson*
2017, Mar 23; 129(12): 1685-1690
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2016

The subclonal architecture of metastatic breast cancer: Results from a Prospective Community Based Rapid Autopsy Program "CASCADE"

PLoS Medicine

P. Savas, Z.L. Teo, C. Lefevre, C. Flensburg, F. Caramia, K. Alsop, M. Mansour, P.A. Francis, H.A. Thorne, M.J. Silva, N. Silva, M. Dietzen, A. Rowan, M. Kschischo, S. Fox, D.D. Bowtell, S.J. Dawson, T.P. Speed, C. Swanton, S. Loi
2016, Dec 27; 13(12):e1002204
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A community -based model of rapid autopsy in end-stage cancer patients

Nature Biotechnology

K. Alsop, H. Thorne, S. Sandhu, A. Hamilton, C. Mintoff, E. Christie, O. Spruyt, S. Williams, O. McNally, L. Mileshkin, S. Ananda, J. Hallo, S. Loi, C. Scott, P. Savas, L. Devereux, P. O'Brien, S. Gunawardena, C. Hampson, K. Strachan, R.D. Jaravaza, V. Francis, G. Young, D. Ranson, R. Samaranayake, D. Stevens, S. Boyle, C. Fedele, M. Topp, G. Ho, Z.L. Teo, R.A. Taylor, M.M. Papargiris, M.G. Lawrence, H. Wang, G.P. Risbridger, N.M. Haynes, M. Medon, R.W. Johnstone, E. Vidacs, G. Mir Arnau, I.A. Vergara, A.T. Papenfuss, G. McArthur, P. Waring, S. Carvosso, C. Angel, D. Gyorki, B. Solomon, G. Mitchell, S. Shanley, P.A. Francis, S.J. Dawson, A. Haffenden, E. Tidball, M. Volchek, J. Pyman, M. Madadin, J. Leditschke, S. Cordner; Melbourne Melanoma Project; Australian Ovarian Cancer Study Group (AOCS); Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), M. Shackleton, D.D. Bowtell
2016 Oct; 34(10): 1010-1014
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Functional interdependence of BRD4 and DOT1L in MLL leukaemia

Nature Structural & Molecular Biology

O. Gilan, E.Y.N. Lam, I. Becher, D. Lugo, E. Cannizzaro, G. Joberty, A. Ward, M. Wiese, C.Y. Fong, S. Ftouni, D. Tyler, K. Stanley, L. MacPherson, C.F. Weng, Y.C. Chan, M. Ghisi, D. Smil, C. Carpenter, P. Brown, N. Garton, M.E. Blewitt, A.J. Bannister, T. Kouzarides, B.J.P. Huntly, R.W. Johnstone, G. Drewes, S.J. Dawson, C.H. Arrowsmith, P. Grandi, R.K. Prinjha, M.A. Dawson*
2016 July; 23(7):673-81
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Id2 and E proteins orchestrate the initiation and maintenance of MLL-rearranged acute myeloid leukaemia

Cancer Cell

M. Ghisi, L. Kats, F. Masson, J. Li, T. Kratina, E. Vidacs, O. Gilan, M. Doyle, A. Newbold, J.E. Bolden, K.A. Fairfax, C.A. de Graaf, M. Firth, J. Zuber, R.A. Dickins, L.M. Corcoran, M.A. Dawson, G.T. Belz, R.W. Johnstone
2016 Jul 11;30(1):59-74
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Dual targeting of bromodomain and extraterminal domain proteins, and WNT or MAPK signaling, inhibits c-MYC expression and proliferation of colorectal cancer cells

Molecular Cancer Therapeutics

L. Tögel, R. Nightingale, A.C. Chueh, A. Jayachandran, H. Tran, T. Phesse, R. Wu, O.M. Sieber, D. Arango, A.S. Dhillon, M.A. Dawson, B. Diez-Dacal, T.C. Gahman, P. Filippakopoulos, A.K. Shiau, J.M. Mariadason
2016 Jun;15(6):1217-26
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2015

BET inhibitor resistance emerges from leukaemia stem cells

Nature

C.Y. Fong, O. Gilan, E.Y.N. Lam, A.F. Rubin, S. Ftouni, D. Tyler, K. Stanley, D. Sinha, P. Yeh, J. Morison, G. Giotopoulos, D. Lugo, P. Jeffrey, S. Chun-Wei Lee, C. Carpenter, R. Gregory, R.G. Ramsay, S.W. Lane, O. Abdel-Wahab, T. Kouzarides, R. Johnstone, S.J. Dawson, B.J.P. Huntly, R.K. Prinjha, A.T. Papenfuss, M.A. Dawson*
2015 Sep; 525(7570): 538-42
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Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

Science

I.A. Tchasovnikarova, R.T. Timms, N.J. Matheson, K. Wals, R. Antrobus, B. Göttgens, G. Dougan, M.A. Dawson, P.J. Lehner
2015 Jun 26;348(6242):1481-5
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CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo

Leukemia

G.P. Gregory, S.J. Hogg, L.M. Kats, E. Vidacs, A.J. Baker, O. Gilan, M. Lefebure, B.P. Martin, M.A. Dawson, R.W. Johnstone, J. Shortt
2015 Jun;29(6):1437-41
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Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2

Blood

S.A. Kinkel, R. Galeev, C. Flensburg, A. Keniry, K. Breslin, O. Gilan, S. Lee, J. Liu, K. Chen, L.J. Gearing, D.L. Moore, W.S. Alexander, M.A. Dawson, I.J. Majewski, A. Oshlack, J. Larsson, M.E. Blewitt
2015 Mar 19;125(12):1890-900
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2014

Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium

The Journal of Pathology: Clinical Research

W.J. Howat, F.M. Blows, E. Provenzano, M.N. Brook, L. Morris, P. Gazinska, N. Johnson, L.A. McDuffus, J. Miller, E.J. Sawyer, S. Pinder, C.H. Van Deurzen, L. Jones, R. Sironen, D. Visscher, C. Caldas, F. Daley, P. Coulson, A. Broeks, J. Sanders, J. Wesseling, H. Nevanlinna, R. Fagerholm, C. Blomqvist, P. Heikkila, H.R. Ali, S.J. Dawson, J. Figueroa, J. Lissowska, L. Brinton, A. Mannermaa, W.E. Mesker, C.M. Seyaneve, A. Hollestelle, J. Benitez, J.I. Perez, P. Menendez, M.K. Bolla, D.F. Easton, M.K. Schmidt, P.D. Pharoah, M.E. Sherman, M. Garcia-Closas
2014 Dec 4; 1(1):18-32
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Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients

Annals of Oncology

H.R. Ali, E. Provenzano, S.J. Dawson, F.M. Blows, B. Liu, M. Shah, H.M. Earl, C.J. Poole, L. Hiller, J.A. Dunn, S.J. Bowden, C. Twelves, J.M. Bartlett, S.M. Mahmoud, E. Rakha, I.O. Ellis, S. Liu, D. Gao, T.O. Nielsen, P.D. Pharoah, C. Caldas
2014 Aug; 25(8): 1536-43
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Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data

The Lancet Oncology

F.C. Bidard, D. Peeters, T. Fehm, F. Nolé, R. Gisbert-Criado, D. Mavroudis, S. Grisanti, D. Generali, J.A. Garcia-Saenz, J. Stebbing, C. Caldas, P. Gazzaniga, L. Manso, R. Zamarchi, A.F. Lascoiti, L. Mattos-Arruda, M. Ignatiadis, R. Lebofsky, S.J. van Laere, F. Meier-Stiegen, M.T. Sandri, J. Vidal-Martinez, E. Politaki, F. Consoli, A. Bottini, E. Diaz-Rubio, J. Krell, S.J. Dawson, C. Raimondi, A. Rutten, W. Janni, E. Munzone, V. Carañana, S. Agelaki, C. Almici, L. Dirix, E. Solomayer, L. Zorzino, H. Johannes, J.S. Reis-Filho, K. Pantel, J.Y. Pierga, S. Michiels
2014 April; 15(4); 406-14
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Breast cancer susceptibility risk associations and heterogeneity by E-cadherin tumor tissue expression

Breast Cancer Research & Treatment

H.N. Horne, M.E. Sherman, M. Garcia-Closas, P.D. Pharoah, F.M. Blows, X.R. Yang, S.M. Hewitt, C.M. Conway, J. Lissowska, L.A. Brinton, L. Prokunina-Olsson, S.J. Dawson, C. Caldas, D.F. Easton, S.J. Chanock, J.D. Figueroa
2014 Jan; 143(1): 181-7
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Recurrent mutations, including NPM1c activate a BRD4 dependent core transcriptional program in Acute Myeloid Leukemia

Leukemia

M.A. Dawson, E.J. Gudgin, S.J. Horton, G. Giotopoulos, E. Meduri, S. Robson, E. Cannizzaro, H. Osaki, M. Wiese, S. Putwain, C.Y. Fong, C. Grove, J. Craig, A. Dittmann, D. Lugo, P. Jeffrey, G. Drewes, K. Lee, L. Bullinger, R.K. Prinjha, T. Kouzarides, G.S. Vassiliou, B.J.P. Huntly
2014 Feb;28(2):311-20
Read more >
BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms

Leukemia

B. Wyspianska, A.J. Bannister, I. Barbieri, J. Nangalia, A. Godfrey, F.J. Calero-Nieto, S. Robson, I. Rioja, J. Li, M. Wiese, E. Cannizzaro, M.A. Dawson, B. Huntly, R.K. Prinjha, A.R. Green, B. Gottgens, T. Kouzarides
2014 Jan;28(1):88-97
Read more >

Review articles

2013

Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-Driven malignancies and overcome acquired resistance to JAK2 inhibitors

Cell Reports

M. Waibel, V.S. Solomon, D.A. Knight, R.A. Ralli, S.K. Kim, K.M. Banks, E. Vidacs, C. Virely, K.C.S. Sia, L.S. Bracken, R. Collins-Underwood, C. Drenberg, L.B. Ramsey, S.C. Meyer, M. Takiguchi, R.A. Dickins, R. Levine, J. Ghysdael, M.A. Dawson, R.B. Lock, C.G. Mullighan, R.W. Johnstone
2013 Nov 27;5(4):1047-59
Read more >
TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

The EMBO Journal

R. Deplus, B. Delatte, M.K. Schwinn, M. Defrance, J. Méndez, N. Murphy, M.A. Dawson, M. Volkmar, P. Putmans, E. Calonne, O. Bernard, T. Mercher, E. Solary, M. Urh, D.L. Daniels, F. Fuks
2013 Mar 6;32(5):645-55
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Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

Nature

M. Murtaza*, S.J. Dawson*, D.W.Y. Tsui*, A.M. Piskorz, C. Parkinson, S.F. Chin, F. Marass, S. Humphray, J. Hadfield, D. Bentley, J.D. Brenton, C. Caldas, N. Rosenfeld (* equal first author)
2013 May 2; 497(7447): 108-12
Read more >
Analysis of circulating tumor DNA to monitor metastatic breast cancer

The New England Journal of Medicine

S.J. Dawson*, D.W.Y. Tsui*, M. Murtaza, H. Biggs, O. Rueda, S.F. Chin, M. Dunning, D. Gale, T. Forshew, B. Mahler-Araujo, S. Rajan, S. Humphray, J. Becq, D. Halsall, M. Wallis, D. Bentley, C. Caldas, N. Rosenfeld (* equal first author)
2013 March 28; 368(13):1199-209
Read more >
Astronomical algorithms for automated analysis of tissue protein expression in breast cancer

British Journal of Cancer

H.R. Ali, M. Irwin, L. Morris, S.J. Dawson, F.M. Blows, E. Provenzano, B. Mahler-Araujo, P.D. Pharoah, N.A. Walton, J.D. Brenton and C. Caldas
2013 Feb 19; 108(3): 602-12
Read more >

2020

Non-genetic mechanisms of therapeutic resistance in cancer

Nature Reviews Cancer

J.C. Marine*, S.J. Dawson*, M.A. Dawson*
2020 Dec;20(12):743-756
Read more >
Targeting the epigenetic regulation of anti-tumor immunity

Nature Reviews Drug Discovery

S.J. Hogg, P.A. Beavis, M.A. Dawson*, R.W. Johnstone
2020 Nov;19(11):776-800
Read more >
The old and the new: DNA and RNA methylation in normal and malignant haematopoiesis

Experimental Hematology

A.A. Guirguis*, B.J. Liddicoat*, M.A. Dawson*
2020 Oct;90:1-11
Read more >

2019

Epigenetic therapies in acute myeloid leukaemia: where to from here?

Blood

K.A. Fennell, C.C. Bell, M.A. Dawson*
2019; Nov 28;134(22):1891-1901
Read more >
The roles of DNA, RNA and histone methylation in ageing and cancer

Nature Reviews Molecular Cell Biology

E. Michalak, M.L. Burr, A.J. Bannister*, M.A. Dawson*
2019 Oct;20(10):573-589
Read more >
Characterising the cancer genome in blood

Cold Spring Harbor Perspectives in Medicine

S.J. Dawson*
2019 Apr 1; 9(4): a026880
Read more >

2018

Understanding resistance mechanisms to BTK and BCL2 inhibitors in mantle cell lymphoma: implications for design of clinical trials

Leukemia & Lymphoma

R. Agarwal, M.A. Dawson, M. Dreyling, C.S. Tam
2018 Dec;59(12):2769-2781
Read more >
The value of cell-free DNA for molecular pathology

The Journal of Pathology

C.M. Stewart, P.D. Kothari, F. Mouliere, R. Mair, S. Somnay, R. Benayed, A. Zehir, B. Weigelt, S.J. Dawson, M.E. Arcila, M.F. Berger, D.W. Tsui
2018 Apr; 244(5):616-627
Read more >

2017

Wet or Dry? Do liquid biopsy techniques compete with or complement PET for disease monitoring?

Journal of Nuclear Medicine

S.Q. Wong, R.W. Tothill, S.J. Dawson, R.J. Hicks
2017 Jun; 58(6): 869-870
Read more >
The cancer epigenome: Concepts, challenges, and therapeutic opportunities

Science

M.A. Dawson*
2017 Mar 17;355(6330):1147-1152
Read more >

2016

Blood worth bottling: circulating tumor DNA as a cancer biomarker

Cancer Research

E.L. Christie, S.J. Dawson, D.D. Bowtell
2016 Oct 1; 76(19):5590-5591
Read more >

2014

Circulating tumor cells and circulating tumor DNA for precision medicine: dream or reality?

Annals of Oncology

M. Ignatiadis, SJ. Dawson*
2014 Dec 25 (12): 2304-13
Read more >
Epigenetics in the hematologic malignancies

Haematologica

C.Y. Fong, J. Morison, M.A. Dawson*
2014 Dec;99(12):1772-1783
Read more >

Review articles

Non-genetic mechanisms of therapeutic resistance in cancer

Nature Reviews Cancer

J.C. Marine*, S.J. Dawson*, M.A. Dawson*
2020 Dec;20(12):743-756
Read more >
Targeting the epigenetic regulation of anti-tumor immunity

Nature Reviews Drug Discovery

S.J. Hogg, P.A. Beavis, M.A. Dawson*, R.W. Johnstone
2020 Nov;19(11):776-800
Read more >
The old and the new: DNA and RNA methylation in normal and malignant haematopoiesis

Experimental Hematology

A.A. Guirguis*, B.J. Liddicoat*, M.A. Dawson*
2020 Oct;90:1-11
Read more >
Epigenetic therapies in acute myeloid leukaemia: where to from here?

Blood

K.A. Fennell, C.C. Bell, M.A. Dawson*
2019; Nov 28;134(22):1891-1901
Read more >
The roles of DNA, RNA and histone methylation in ageing and cancer

Nature Reviews Molecular Cell Biology

E. Michalak, M.L. Burr, A.J. Bannister*, M.A. Dawson*
2019 Oct;20(10):573-589
Read more >
Characterising the cancer genome in blood

Cold Spring Harbor Perspectives in Medicine

S.J. Dawson*
2019 Apr 1; 9(4): a026880
Read more >
The clinical use of circulating tumor cells (CTCs) enumeration for staging of metastatic breast cancer (MBC): International expert consensus paper

Critical Reviews in Oncology / Hematology

M. Cristofanilli, J.Y. Pierga, J. Reuben, A. Rademaker, A.A. Davis, D.J. Peeters, T. Fehm, F. Nolé, R. Gisbert-Criado, D. Mavroudis, S. Grisanti, M. Guiliano, J.A. Garcia-Saenz, J. Stebbing, C. Caldas, P. Gazzaniga, L. Manso, R. Zamarchi, A.F. de Lascoiti, L. De Mattos-Arruda, M. Ignatiadis, L. Cabel, S.J. van Laere, F. Meier-Stiegen, M.T. Sandri, J. Vidal-Martinez, E. Politaki, F. Consoli, D. Generali, M.R. Cappelletti, E. Diaz-Rubio, J. Krell, S.J. Dawson, C. Raimondi, A. Rutten, W. Janni, E. Munzone, V. Carañana, S. Agelaki, C. Almici, L. Dirix, E.F. Solomayer, L. Zorzino, L. Darrigues, J.S Reis-Filho, L. Gerratana, S. Michiels, F.C. Bidard, K. Pantel
2019 Feb; 134:39-45
Read more >
Understanding resistance mechanisms to BTK and BCL2 inhibitors in mantle cell lymphoma: implications for design of clinical trials

Leukemia & Lymphoma

R. Agarwal, M.A. Dawson, M. Dreyling, C.S. Tam
2018 Dec;59(12):2769-2781
Read more >
The value of cell-free DNA for molecular pathology

The Journal of Pathology

C.M. Stewart, P.D. Kothari, F. Mouliere, R. Mair, S. Somnay, R. Benayed, A. Zehir, B. Weigelt, S.J. Dawson, M.E. Arcila, M.F. Berger, D.W. Tsui
2018 Apr; 244(5):616-627
Read more >
Wet or Dry? Do liquid biopsy techniques compete with or complement PET for disease monitoring?

Journal of Nuclear Medicine

S.Q. Wong, R.W. Tothill, S.J. Dawson, R.J. Hicks
2017 Jun; 58(6): 869-870
Read more >
The cancer epigenome: Concepts, challenges, and therapeutic opportunities

Science

M.A. Dawson*
2017 Mar 17;355(6330):1147-1152
Read more >
Blood worth bottling: circulating tumor DNA as a cancer biomarker

Cancer Research

E.L. Christie, S.J. Dawson, D.D. Bowtell
2016 Oct 1; 76(19):5590-5591
Read more >
Circulating tumor cells and circulating tumor DNA for precision medicine: dream or reality?

Annals of Oncology

M. Ignatiadis, SJ. Dawson*
2014 Dec 25 (12): 2304-13
Read more >
Epigenetics in the hematologic malignancies

Haematologica

C.Y. Fong, J. Morison, M.A. Dawson*
2014 Dec;99(12):1772-1783
Read more >